"On the Road Again," a song recorded by the American blues rock group Canned Heat, was released as a single in April 1968, and appeared on their 1968 album Boogie with Canned Heat as well as the 1969 compilation The Canned Heat Cookbook. It reached number eight on the UK Singles Chart and number sixteen on the Billboard Hot 100.
"On the Road Again" was adapted by Alan Wilson from a song of the same name recorded in 1953 by Floyd Jones (July 21, 1917 – December 19, 1989), a Chicago blues musician. Jones' song was itself an adaptation of "Big Road Blues," recorded in 1928 by Delta blues musician Tommy Johnson.
With his knowledge of Eastern music, Wilson used a tambura drone to give the song a hypnotic effect and a psychedelic edge. The song features Wilson as the lead singer and harmonica player. Wilson's harmonica solo has a note that is not playable without an overblow; he re-tuned his harmonica's six hole up a half step. The B-side of the single was entitled "Boogie Music". A black and white live performance is used in place of a video.